
BIAZZI-Standard-Pharma-Skid (BSPS)
LET‘S TALK ABOUT THE
BIAZZI-STANDARD-PHARMA-SKID (BSPS)

- Multipurpose
- Modular
- Easy to operate
- Gas/liquid and liquid/liquid reactions
at a glance:
- Operated in batch
- 50lt-250lt
- -1 to 10 barg max.
- from -20°C to 150°C
- Optimal heat transfer
- GMP-compliant
- CE conformance
- ATEX-conformance
Why the BSPS ?
The pharmaceutical industry and mainly Custom Manufacturing Organization’s need a tool to be able to produce API’s and intermediates. These may require hydrogenation and/or other gas/liquid reactions, including catalyst-filtration, distillation, condensation and cover a wide range of conditions of the daily business in Pharma such as:
- batch operation
- temperature -20°C to 150°C
- pressure -1 barg up to 10 barg
- pH range 1 to 14
- slurry (solid/liquid/gas)
- multipurpose (e.g. various gas/liquid reactions)
- etc.
Additionally, the unit has to be available quickly and provide a cost-effective investment.
Right TIME for the BSPS
With these objectives in mind, BIAZZI answered the call to develop a high end, multipurpose standardized offering, while also providing various options for customization. The Biazzi BSPS is an optimal production tool, easy to implement, effective, and available for a minimal capital investment.
BIAZZI is offering the following multipurpose batch wise operated gas-liquid plant, supplied as skid mounted unit. The plant enables to perform hydrogenation, oxidation, carbonylation and amination reactions. Beside Gas-Liquid-reactions and/or Liquid-Liquid-reactions can be run.
These process equipment and main process can be schematized as follows:

Operating conditions and properties of the BSPS:
- 50lt – 250lt useful
- -20/150°C
- -1/10 barg
- Material of construction: Hastelloy C22
- cGMP compliant CE-marking
- Clear separation between process and utility sides
- Gas aspiring turbine providing high mass-transfer
- Complete unit to perform Gas-Liquid and/or Liquid-Liquid-reactions including solvent reflux/distillation
The BSPS is designed for
Products:
Active pharmaceutical ingredients and/or intermediates in aqueous solution or in solvents.
Solvents:
Most common solvents that can be used are:
Alcohols
Isopropanol
Isobutanol
Ethanol
Methanol
Etc.
Ethers
Methyl-THF
Dioxane
Ethyl ether
Tetrahydrofuran
Etc.
Ketones
Acetone
Methyl Ethyl Ketone (MEK)
Etc.
Esters
Ethyl acetate
Etc.
Halogen based solvents
Ethylene bromide
Dichloromethane
Tetrachloroethylene
Diluted acids
Hydrochloric acid
Acetic Acid
Etc.
Aliphatic
Cyclohexane
Hexane
Etc.
Aromatics
Toluene
Xylene
Etc.
Alkaline diluted compounds
Sodium- / Potassium-Hydroxide
Ammonia-Solution
Catalysts:
Typical heterogeneous catalysts used for gas-liquid reactions:
- Sponge metal-type catalysts
- Noble metal-type catalysts
- Etc.
SUPPLIED BSPS
Scope of supply of the BSPS-BASIS-MODEL
- SKID-Mounted Unit with all valving, piping, insulation and instrumentation
- All equipment needed for gas/liquid or liquid/liquid reactions:
- Reactor with turbine agitator
- Containment device for raw material / catalyst feeding
- Heating / cooling system
- Condenser for solvent reflux or distillation
- Control system (hardware + program) with local control panel (HMI)
- Engineering documentation (P&ID’s, specifications, FS, etc.)
- Validation (FAT + IQ/OQ)
- Technical documentation (operating and maintenance instructions, CE marking)

BSPS-Basis model. Dimensions: 2.2m (L) x 2.2m (W) x 3.2m (H)
Options available for the BSPS
- Preparation vessel
- Filtration system
- Sampling valve
- Off-gas scrubbing system

BSPS-All options model. Dimensions: 3.1m (L) x 2.2m (W) x 3.2m (H)
A TOOL, TO LET GROW YOUR SUCCESS !
YOU WANT MORE? TELL US…
Please contact us:
- Complete the contact form
- Fill in the “Subject” field: BSPS
- Fill in the “Message” field: Please send me an offer for the BSPS
or contact us by phone:
+41 21 989 21 21